{"id":2597,"date":"2005-08-31T15:59:00","date_gmt":"2005-08-31T15:59:00","guid":{"rendered":"https:\/\/gutheroes.com\/?p=2597"},"modified":"2022-09-11T18:29:56","modified_gmt":"2022-09-11T18:29:56","slug":"phytochemistry-ibuprofen-like-activity-in-extra-virgin-olive-oil","status":"publish","type":"post","link":"https:\/\/gutheroes.com\/research\/phytochemistry-ibuprofen-like-activity-in-extra-virgin-olive-oil\/","title":{"rendered":"Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil"},"content":{"rendered":"\n<p class=\"has-text-align-center radius-corners has-background has-small-font-size\" style=\"background-color:#abb7c229\"><strong>Published: <\/strong>31st August, 2005<br><em><strong>Authors: <\/strong>Gary K Beauchamp, Russell S J Keast, Diane Morel, Jianming Lin,<\/em><br><em>Jana Pika, Qiang Han, Chi-Ho Lee, Amos B Smith, Paul A S Breslin<\/em><\/p>\n\n\n\n<div style=\"height:34px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Abstract:<br><\/strong><br>&#8220;Newly pressed extra-virgin olive oil contains oleocanthal&#8211;a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen.<\/p>\n\n\n\n<p>We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. <\/p>\n\n\n\n<p>Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.&#8221;<\/p>\n\n\n\n<p><strong>Notes from Study:<\/strong><\/p>\n\n\n\n<p>&#8220;We found that, like ibuprofen, both enantiomers of oleocanthal caused dose-dependent inhibition of COX-1 and COX-2 activities but had no effect on lipoxygenase in vitro.<\/p>\n\n\n\n<p>Our findings raise the possibility that long term consumption of oleocanthal may help to protect against some diseases by virtue of its ibuprofen-like COX-inhibiting activity.<\/p>\n\n\n\n<p>If 50 g of extra-virgin olive oil containing up to 200g per ml oleocanthal is ingested per day, of which 60\u201390% is absorbed8,9, then this corresponds to an intake of up to 9 mg per day.<\/p>\n\n\n\n<p>This dose is relatively low, corresponding to about 10% of the ibuprofen dosage recommended for adult pain relief, but it is known that regular low doses of aspirin, for example, another COX inhibitor, confer cardiovascular health benefits.<\/p>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-1 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-50\"><a class=\"wp-block-button__link has-black-background-color has-background\" href=\"https:\/\/www.nature.com\/articles\/437045a\" target=\"_blank\" rel=\"noreferrer noopener\">View this study here<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Published: 31st August, 2005Authors: Gary K Beauchamp, Russell S J Keast, Diane Morel, Jianming Lin,Jana Pika, Qiang Han, Chi-Ho Lee, Amos B Smith, Paul A S Breslin Abstract:&#8220;Newly pressed extra-virgin olive oil contains oleocanthal&#8211;a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":132,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[5],"tags":[],"_links":{"self":[{"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/posts\/2597"}],"collection":[{"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/comments?post=2597"}],"version-history":[{"count":7,"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/posts\/2597\/revisions"}],"predecessor-version":[{"id":2606,"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/posts\/2597\/revisions\/2606"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/media\/132"}],"wp:attachment":[{"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/media?parent=2597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/categories?post=2597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gutheroes.com\/wp-json\/wp\/v2\/tags?post=2597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}