Shangzhu Zhang, Yanhong Wang, Linyi Peng, Jinmei Su, Xiaofeng Zeng, Mengtao Li, Zhenbiao Wu, Jian Xu, Min Yang, Lijun Wu, Cheng Zhao, Xinwang Duan, Qin Li, Jing Zhu and Wenqiang Fan

Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
Department of Epidemiology and Bio-Statistics (YW), Peking Union Medical College, Institute of Basic Medical Sciences, China Academy of Medical Sciences, Beijing, China
Department of Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Xi’an, China
Department of Rheumatology, Kunming Medical University First Affiliated Hospital, Kunming, China
Department of Rheumatology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, China
Department of Rheumatology, The People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China
Department of Rheumatology, Guangxi Medical University First Affiliated Hospital, Nanning, China
Department of Rheumatology, Nanchang University Second Affiliated Hospital, Nanchang, China
Department of Rheumatology, First People’s Hospital of Yunnan, Kunming, China
Department of Rheumatology, Sichuan Provincial People’s Hospital, Chengdu, China
Department of Rheumatology, Xinxiang Central Hospital, Xinxiang, China

Published: 23rd December 2020

Objective:

“The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.”

Methods:

“An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence.”

Results:

“We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender (p < 0.001), younger age (p < 0.001), a disease duration of more than 3 years (p < 0.001), a family history of SpA (p < 0.001), uveitis (p < 0.001), ASDAS-CRP (p < 0.001), and biologic treatment (p < 0.001) were the main variables that were independently related to HLA-B27 presence, whereas a diagnosis delay time >36 months (p < 0.001) and psoriasis (p < 0.001) were independently related to HLA-B27 absence.”

Conclusion:

“In Chinese axial SpA patients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis.”

You can see full details on this study here