Ankylosing Spondylitis Research
Essential Reading
Here is a list of ‘must read’ papers that relate the potential impact of diet to help manage this condition. I’ve tried to highlight, where possible, some of the more interesting (and actionable) findings.
Treating Ankylosing Spondylitis with a Low or No Starch Diet
Report Title: “The Use of a Low Starch Diet in the Treatment of Patients Suffering from Ankylosing Spondylitis”
The Role of 'Leaky Gut' in Autoimmune Diseases
Report Title: “Leaky Gut and Autoimmunity: An Intricate Balance in Individuals Health and the Diseased State”
17 Years: The Slow Journey from Scientific Discovery to Treatment
Report Title: “The answer is 17 years, what is the question: understanding time lags in translational research”
The Klebsiella Bacteria and Ankylosing Spondylitis Connection
Report Title: “The Association of HLA-B27 and Klebsiella Pneumoniae in Ankylosing Spondylitis: A Systematic Review”
Sugar, Inflammation and Autoimmune Diseases
Report Title: “The Glucose Transporter GLUT3 Controls T Helper 17 Cell Responses Through Glycolytic-epigenetic Reprogramming”
New Study - The Low Starch Diet as an AS Treatment! Awaiting Results...
Report Title: “Effect of a Low Starch Diet in Patients With Ankylosing Spondylitis”
Looking for a specific study? Search here:
✅ Practical Steps
Below are some relevant studies which specifically cover inflammation, gut function and autoimmune disease. They cover simple, practical steps you can take to stay healthy with your diet and day to day life:
More Studies
Here is the full list of studies I’ve referenced on this website along with synopses where possible.
As well as ankylosing spondylitis specific studies, I’ve also included relevant studies on autoimmune disorders in general, rheumatoid arthritis and anything to do with gut permeability (‘leaky gut’) or inflammation
Number of Studies
The Association of HLA-B27 and Klebsiella Pneumoniae in Ankylosing Spondylitis: A Systematic Review
Li Zhanga, Yan-Jie Zhangb, Jin Chenc, Xiao-Lei Huangb, Gong-Si Fangc, Li-Juan Yangb, Yu Duanb, Jing Wangb Medical Genetics Center, Anhui Medical College, Hefei, China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University,...
Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis
Published: 13th January, 2018Authors: James J DiNicolantonio, James H O’Keefe, and William Wilson In Summary: Magnesium could be essential in the prevention (and treatment) of chronic disease If deficient magnesium "can be pulled from the bone (as well as...
Relationship Between Diet and Ankylosing Spondylitis: A Systematic Review
Tatiana V. Macfarlane, Hadeel M. Abbood, Ejaz Pathan, Katy Gordon, Juliane Hinz, and Gary J. Macfarlane Published: 25th October 2017 Abstract: "The question of whether diet plays a role in the onset of ankylosing spondylitis (AS) or can affect the course of the...
Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions
Published: 25th March, 2015Authors: RadhaKrishna Rao and Geetha Samak In Summary: Disruption to gut barrier function could play a crucial role in autoimmune diseasesL-Glutamine is an amino acid which helps maintain mucosal integrity (gut barrier function)There's...
The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases Throughout Life and the Role of Nutrition in Optimizing Treatment Strategies
Published: January, 2015. Authors: Selma P. Wiertsema, Jeroen van Bergenhenegouwen, Johan Garssen and Leon M. J. KnippelsIn Summary 70% - 80% of your immune cells live in your gut The microbiota (bacteria, viruses, fungi, and protozoa) in your gut has to compete with...
Raised Incidence of Ankylosing Spondylitis Among Inuit Populations Could Be Due to High HLA‑B27 Association and Starch Consumption
Taha Rashid · Clyde Wilson · Alan Ebringer Published: 11th November 2014 Abstract: "Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting the spinal joints. It would appear that the most likely causative agent in the development of AS is an...
Increased Frequency of Restless Leg Syndrome in Patients with Ankylosing Spondylitis
Aslan Tekatas, Omer N. Pamuk Published: 25 February 2014 Objective: "To assess the prevalence of restless leg syndrome (RLS) in patients with ankylosing spondylitis (AS) and to investigate factors potentially associated with RLS." Methods: "One hundred and thirty...
The Use of a Low Starch Diet in the Treatment of Patients Suffering from Ankylosing Spondylitis
Published: 22nd February, 2014Authors: A. Ebringer, Clyde Wilson In Summary: In an initial study of 36 AS patients following the "low starch diet" the majority reported "the severity of their symptoms declined and in some cases completely disappeared" The "low...
Human Demodex Mite: The Versatile Mite of Dermatological Importance
Abstract: "Demodex mite is an obligate human ecto-parasite found in or near the pilo-sebaceous units. Demodex folliculorum and Demodex brevis are two species typically found on humans. Demodex infestation usually remains asymptomatic and may have a pathogenic role...
Global Prevalence of Ankylosing Spondylitis
Linda E. Dean, Gareth T. Jones, Alan G. MacDonald, Christina Downham, Roger D. Sturrock, Gary J. Macfarlane Published: 9th December 2013 Abstract: "For effective health care provision, knowledge of disease prevalence is paramount. There has been no systematic...
Prevalence of HLA-B27 in the New Zealand Population: Effect of Age and Ethnicity
Rebecca L Roberts, Mary C Wallace, Gregory T Jones, Andre M van Rij, Tony R Merriman, Andrew Harrison, Douglas White, Lisa K Stamp, Daniel Ching, John Highton & Simon M Stebbings Published: 22nd October 2013 Introduction: "HLA-B27 genotyping is commonly used to...
HLA-B27-Mediated Protection in HIV and Hepatitis C Virus Infection and Pathogenesis in Spondyloarthritis
Neumann-Haefelin, Christoph Published: July 2013 Abstract: "HLA-B27 is associated with low viral load and long-term nonprogression in HIV infection as well as spontaneous clearance of hepatitis C virus (HCV) infection. This review summarizes mechanisms that have been...
The Link Between Ankylosing Spondylitis, Crohn’s Disease, Klebsiella, and Starch Consumption
Published: 27th May, 2013Authors: Taha Rashid, Clyde Wilson, A. Ebringer In Summary: Significantly more "anti-Klebsiella antibodies" have been found in samples taken from AS patients Starch promotes the "growth, replication, and persistence of... Klebsiella...
Petroleum Jelly Versus Tea Tree Oil and Tea Tree Facial Wash Lid Scrub in Patients with Blepharitis Associated with Above-normal Demodex Count
Karen Angela L. Tiuseco, MD, Ruben Lim Bon Siong, MD, Johann Michael Reyes, MD, and Eleonor B. Iguban, MD Published: December 2012 About: "Blepharitis is a common, often chronic, and recurrent ocular disease characterized by inflammation of the eyelid margin. The most...
Study: 17 Years – The Slow Journey from Scientific Discovery to Treatment in Patients
Title: "The answer is 17 years, what is the question: understanding time lags in translational research" Published: December, 2011 | 🔗 View this study here | Authors: Zoë Slote Morris, Steven Wooding, and Jonathan Grant In Summary: It's often...
Molecular mechanisms of inflammation. Anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal
Published: 2011Authors: Lisa Lucas, Aaron Russell and Russell Keast Abstract:"Chronic inflammation is a critical factor in the pathogenesis of many inflammatory disease states including cardiovascular disease, cancer, diabetes, degenerative joint diseases and...
Unlocking the Genetics and Biology of Joint Disorder Ankylosing Spondylitis
Wellcome Trust Published: July 11, 2011 Summary: "A study involving over 5,000 people living with the joint disorder ankylosing spondylitis has identified a series of genetic variants associated with increased susceptibility to the condition as well as providing new...
Fatty Acids From Fish: The Anti-Inflammatory Potential of Long-Chain Omega-3 Fatty Acids
Published: May 1, 2010 Authors: Rebecca Wall, R Paul Ross, Gerald F Fitzgerald, Catherine Stanton In Summary: A typical Western diet has too many omega-6 fats. This can increase inflammation and contribute to chronic diseases Omega-3 fats found in fish like...
Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil
Published: 31st August, 2005Authors: Gary K Beauchamp, Russell S J Keast, Diane Morel, Jianming Lin,Jana Pika, Qiang Han, Chi-Ho Lee, Amos B Smith, Paul A S Breslin Abstract:"Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces...
Spondyloarthropathies in sub-Saharan Africa
M Mijiyawa, O Oniankitan, M A Khan Published: July 2000 Abstract: "HLA-B27 is virtually absent in most of the sub-Saharan Africa populations, and ankylosing spondylitis is rare; only a few patients have been reported from central and southern Africa. HLA-B27 was...
HLA B27 in the Population of Northern Sweden
A Bjelle, B Cedergren, S R Dahlqvist Published: June 1982 Abstract: "The frequency of HLA B27 in blood donors born in northern Sweden was found to be 16.6%. This was significantly higher than in southern Sweden or in caucasians generally, with the exception of...